Embryonic perfect repair inspired electrospun nanofibers dressing with temperature-sensitive and antibacterial properties for wound healing

Introduction The development of highly effective wound dressings is crucial for successful clinical applications. Achieving closure, preventing infection, and minimizing scarring are key objectives in healing. Drawing inspiration from the regenerative mechanisms observed embryonic tissue repair, we designed a series wound-contractible with exceptional antibacterial properties. Methods This was achieved by encapsulating quaternized silicone (QP12) poly( N -isopropylacrylamide-co- -hydroxymethylacrylamide-co-octadecyl acrylate) (PNNS) within electrospun nanofibers poly(ε-caprolactone) (PCL). Results discussion resulting nanofibrous demonstrated remarkable thermo-responsive self-contraction adhesion capabilities, enabling secure adherence to skin active closure. Notably, these exhibited potent activity against both Gram-positive Gram-negative bacteria. Furthermore, they possessed desirable properties such as hydrophilicity, biocompatibility mechanical resembling human skin. A full-thickness defect model evaluation revealed that temperature-sensitive expedited enhanced healing, suppressed scar formation. result evidenced reduced infiltration inflammatory cells, well-organized collagen arrangement, improved vascularization. In summary, propose nanofibers, their anti-scarring properties, hold great promise an advanced solution repair.